Shigatoxin Vaccine for preventing oedema disease.
Single intramuscular 1 ml injection per piglet
Can be used from 4 days of age.
Onset of immunity in 21 days after vaccination.
Long lasting protection of 15 weeks.
Provides protection during critical period from weaning to fattening.
Available from your vet in convenient 50 ml/ 50 dose vials.
Ecoporc Shiga is a new and unique shigatoxin veterinary vaccine which protects piglets from Oedema disease.
Ecoporc Shiga has already proven itself in Germany, where it was developed by IDT Biologika GmbH, as well as in other countries in Europe including France, Spain, Denmark, The Netherlands and Belgium.
The vaccine is given as a single 1 ml intramuscular dose and can be used from 4 days of age. Immunity takes 3 weeks to fully develop and has been proven to last for at least 15 weeks which will give protection during the critical risk period and up to fattening.
The vaccine specifically protects piglets from the potentially lethal effects of shigtoxin, a potent naturally occurring toxin produced by certain types of Escherichia coli. This toxin is sometimes also called verotoxin and the E. coli producing it can be abbreviated as STEC or VTEC.
Ecoporc Shiga is not therefore a vaccine for E coli but specifically for the Shiga toxin produced by certain types of E coli which are known to cause Oedema Disease and it is therefore essential that vets and their farmers correctly identify that the cause of Oedema disease involves the shiga toxin producing E coli (STEC) if full benefits of the vaccine are to be achieved.
A specific test, called the STEC-Check, is available free of charge to Veterinarians and their pig clients to help identify the E coli types involved before the vaccine is used.
This vaccine is only available through your veterinarian and for more information or to discuss further please speak to your Vet.
A significant proportion of Shigatoxin-producing E.coli (STEC) are also able to produce heat resistant [ST] and heat sensitive [LT] enterotoxin in addition to Shigatoxin.
Spread of the disease
Oedema disease is a lethal infectious disease, which is seen in pig production throughout the world. It primarily occurs in piglets during the first two weeks after weaning and is caused by a proliferation of specific Shigatoxin-producing E.coli bacteria (STEC), which is known as Verotoxin. A German study to differentiate pathogenic E. coli bacteria in weaning pigs found STEC in 34% of cases (Sting and Stermann 2008).
Synlab.vet GmbH in Leipzig analysed the samples received in 2011/2012 and, with the aid of PCR, found E.coli strains, which can produce Shigatoxin Stx2e, in 37 % of cases.
Oedema disease usually occurs within the first two weeks after weaning. The heavier and best-developed animals within a group are especially affected. Older animals only develop the disease in limited cases.
The clinical picture of Oedema disease is triggered by a proliferation of STEC in the intestine followed by Shigatoxin Stx2e synthesis.
This is made more likely by a number of stress related factors which may include:
a change in feed after weaning
buffering capacity of feed is too high
lack of thorough acidification of feed mash in the stomach
differentials in environmental temperature and
ranking fights within the pen
Shigatoxin is one of the most potent, naturally occurring poisons and it destroys the very fine blood vessels, the capillaries, and causes fluid accumulation in the tissue. It particularly affects the intestines, hypodermis and brain. For this reason, animals that do not suddenly die of a peracute incidence of the disease, suffer Oedema (an accumulation of fluid) of the eyelids, bridge of the nose and intestines. The animals may also present with fits and convulsions, paralysis and may be seen lying on their side paddling as a result of neurological deficits.
Studies show, that a significant proportion of STEC are also able to produce heat resistant [ST] and heat sensitive [LT] enterotoxins in addition to Shigatoxin and this explains why in some nurseries, diarrhoea and subsequently dehydration are the main concern directly after weaning, but during the course of nursery major losses occur due to Oedema disease.
A distinctive sign of laryngeal Oedema is an unusual, high-pitched squeal of the pigs. It is the level of Ecoli infection and the dose of the shiga toxin within the pig which determines whether the pig dies within hours or remains to be reared as a runt lacking in performance behind its pen mates.
Sub-clinical infections of Shiga Toxin Producing E coli are not uncommon and are particularly suspected to be a contributory factor responsible for reduced productivity within the herd which may include reduced daily weight gain. poor feed conversion and a significant discrepancy in growth in pig breeding (Bosworth et al. 1996).
How Shigatoxin causes Oedema disease – a short video …
Explore in the film, how E. coli Shigatoxin triggers the Oedema disease
A limited number of laboratories have now been validated to perform an STEC test and can offer the so-called ‘STEC-Check’.
Either a faecal swab taken from the clinically sick animal, or a section of the small intestine removed after necropsy is examined in the laboratory.
Hysolv Animal Health UK in association with IDT-Biologika GmbH offers vets and their client Pig farmers, who would like to know the Shigatoxin status of their livestock, a free diagnosis voucher for a Shigatoxin check.
How the STEC check works
In order to diagnose with certainty the presence of shiga toxin producing E.coli on a farm, Hysolv Animal Health and IDT offers you a free laboratory analysis of feces samples or parts of the jejunum. IDT technical service is also happy to help vets in the interpretation of results. .
Get more information about the STEC-CHECK >>>